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NCLEX-RN Safety & Infection Control Practice Test
- Based on the official NCLEX-RN exam guidelines
- Updated for June 2026
Welcome to the first practice test on Safety and Infection Control. This is an important subcategory of the Safe and Effective Care Environment; the official description states, “…the nurse protects clients and health care personnel from health and environmental hazards.” About 12% of NCLEX questions will cover the topics in this category; the range is 9-15%. As a new nurse, you are expected to have an understanding of your responsibility in identifying and preventing potential safety hazards and transmission of pathogens. The responsibility extends beyond the clients to yourself and your colleagues. This practice test will include questions about identifying risks for falls, nurse actions in disaster situations, needlesticks, isolation protocols, and clarifying health care provider (HCP) medication orders. Begin this test at any time. If you leave any test before it’s finished, it will remind you where you are when you return. Read each question carefully and try to think of the answer. If you need help, click on the Hint button that’s under the fourth option to get a sentence that serves as a reminder. If you select the correct response, you’ll automatically advance to the next question. If you make a mistake, an explanation will immediately pop up to provide the rationale for the correct answer. Each time you take a practice test, the questions and options are shuffled into a different random order. These are two proven techniques that reinforce your learning.
- Perfect for nursing students and professionals preparing for the NCLEX exam
- Triple-checked for accuracy by nursing experts
Practice focus
What to focus on before you start
Recent learner results from 6 tracked questions in this set point to Infection Control, Isolation & PPE as the main risk area. The toughest tracked question in this set was missed by about 68% of learners.
Safety & Infection Control
Primary NCLEX area
Infection Control, Isolation & PPE
Hardest tracked topic
68%
Highest miss rate
Hardest topics in this set
- 68% Infection Control, Isolation & PPE
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Foundational nursing review
Founding Nursing Adviser, RN | MHS, Governors State University, IL
Test design and learning experience oversight
Co-Founder & CEO, Elegant E-Learning
Questions are created and maintained by the Nurse Plus Academy content team following our multi-layer editorial process and updated whenever the National Council of State Boards of Nursing changes its guidelines or exam blueprint.
Official sources we check: NCLEX website, Official NCLEX exam blueprint 2026
About the official exam: 75-145 questions • 5 hours • Computer Adaptive • Pass/Fail
How we keep NCLEX practice questions accurate
Our NCLEX practice tests are built around the written knowledge exam and the skills topics nurse aide candidates are expected to know.
Written by Andrei Zakhareuski
Updated over a week ago
At Nurse.plus, we review question wording, answer choices, and explanations against current nurse aide exam topics instead of treating old quiz banks as final.
Here's how we keep the practice tests useful and reliable.
Content creation and review process
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Exam alignment:
We map practice questions to core NCLEX exam areas, including basic nursing skills, infection control, residents' rights, safety, communication, and personal care. -
Clear explanations:
Each question is checked for plain language, answer-choice clarity, and an explanation that helps after a wrong answer. -
Foundational nursing review:
Winona Suzanne Ball, RN, MHS, helped establish the nursing review standards behind Nurse Plus. New updates are maintained by the Nurse.plus content team and checked before publication. -
Editorial QA:
Before a question goes live, we review the clinical point, the distractors, formatting, proofreading, and whether the item fits the test it appears in. -
User feedback:
Every question can be reported from the test screen. When a learner flags wording, an answer choice, or a rationale, we review it and update the item when needed. -
Ongoing updates:
We refresh examples, explanations, and provider references as NCLEX testing guidance changes.
That process is not flashy, but it matters: learners need practice questions that read like the exam and explanations that actually help after a missed answer.
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