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NCLEX-RN Practice Questions: Safety & Infection Control (2026)

  • Based on the official NCLEX-RN exam guidelines
  • Updated for June 2026
  • Perfect for nursing students and professionals preparing for the NCLEX exam
  • Triple-checked for accuracy by nursing experts
Welcome to the second practice test on Safety and Infection Control, one of the subcategories of the Client Need, Safe and Effective Care Environment. When you sit for your NCLEX, you can expect about 12% of the test items from Safe and Effective Care Environment, anywhere from 9 to 31 questions, depending on how long your examination is. (There will be 75-265 questions.) The content covers: Accident/Error/Injury Prevention; Ergonomic Principles; Handling Hazardous and Infectious Materials; Home Safety; Reporting Incidents/Variances, Standard Precautions/Transmission-Based Precautions/Surgical Asepsis, Safe Use of Equipment, and Use of Restraints and Safety Devices. This practice test includes questions about home safety, nursing care outside acute settings, client identification, hand hygiene, and medication issues. Start this test whenever you’re ready. If you leave any test before it’s completed, it will remind you where you left off when you return. Read each question carefully and try to think of the answer before looking at the options. Remember to select the BEST choice. If you’re not sure, click on the Hint button under the fourth option to get a clue. When you select the correct response, you’ll go the next question. If you make a mistake, an explanation will immediately pop up. Each time you take a practice test, the questions and options are shuffled into a different random order. Both of these techniques have been proven to reinforce your learning.
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  • Perfect for nursing students and professionals preparing for the NCLEX exam
  • Triple-checked for accuracy by nursing experts

Practice focus

What to focus on before you start

Recent learner results from 3 tracked questions in this set point to Infection Control, Isolation & PPE as the main risk area. The toughest tracked question in this set was missed by about 31% of learners.

Safety & Infection Control Primary NCLEX area
Infection Control, Isolation & PPE Hardest tracked topic
31% Highest miss rate

Hardest topics in this set

  1. 31% Infection Control, Isolation & PPE

Foundational nursing review

Winona Suzanne Ball

Founding Nursing Adviser, RN | MHS, Governors State University, IL

Test design and learning experience oversight

Andrei Zakhareuski

Co-Founder & CEO, Elegant E-Learning

Questions are created and maintained by the Nurse Plus Academy content team following our multi-layer editorial process and updated whenever the National Council of State Boards of Nursing changes its guidelines or exam blueprint.

Official sources we check: NCLEX website, Official NCLEX exam blueprint 2026

About the official exam: 75-145 questions • 5 hours • Computer Adaptive • Pass/Fail

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