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NCLEX-PN Safety & Infection Control Practice Test
- Based on the official NCLEX-PN exam guidelines
- Updated for June 2026
Welcome to the NCLEX-PN practice test for Safety and Infection Control, a subcategory of the Client Need, Safe and Effective Care Environment. The LPN/VN plays an essential role in protecting clients and team members from health and environmental hazards. Between 10 to 16% of NCLEX-PN test items will be about these important nursing responsibilities in various settings. The content in Safety and Infection Control includes accident and injury prevention, emergency response plan, ergonomic principles, handling hazardous and infectious materials, home safety, incident and variance reports, and proper use of restraints and safety devices. Standard precautions, transmission-based precautions, and surgical asepsis are also included in this section. Questions in this practice test cover disease transmission, preventing infections, fire safety, hand hygiene, client allergies, and CDC precautions. Start this test whenever you’re ready. If you leave any test before it’s completed, it will remind you where you left off when you return. Read each question carefully and try to think of the answer before looking at the options. Remember to select the BEST choice. If you’re not sure, click on the Hint button under the fourth option to get a clue. When you select the correct response, you’ll go the next question. If you make a mistake, an explanation will immediately pop up. Each time you take a practice test, the questions and options are shuffled into a different random order. Both of these techniques have been proven to reinforce your learning.
- Perfect for nursing students and professionals preparing for the NCLEX exam
- Triple-checked for accuracy by nursing experts
Practice focus
What to focus on before you start
Recent learner results from 5 tracked questions in this set point to Infection Control, Isolation & PPE as the main risk area. The toughest tracked question in this set was missed by about 39% of learners.
Safety & Infection Control
Primary NCLEX area
Infection Control, Isolation & PPE
Hardest tracked topic
39%
Highest miss rate
Hardest topics in this set
- 39% Infection Control, Isolation & PPE
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Foundational nursing review
Founding Nursing Adviser, RN | MHS, Governors State University, IL
Test design and learning experience oversight
Co-Founder & CEO, Elegant E-Learning
Questions are created and maintained by the Nurse Plus Academy content team following our multi-layer editorial process and updated whenever the National Council of State Boards of Nursing changes its guidelines or exam blueprint.
Official sources we check: NCLEX website, Official NCLEX exam blueprint 2026
About the official exam: 75-145 questions • 5 hours • Computer Adaptive • Pass/Fail
How we keep NCLEX practice questions accurate
Our NCLEX practice tests are built around the written knowledge exam and the skills topics nurse aide candidates are expected to know.
Written by Andrei Zakhareuski
Updated over a week ago
At Nurse.plus, we review question wording, answer choices, and explanations against current nurse aide exam topics instead of treating old quiz banks as final.
Here's how we keep the practice tests useful and reliable.
Content creation and review process
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Exam alignment:
We map practice questions to core NCLEX exam areas, including basic nursing skills, infection control, residents' rights, safety, communication, and personal care. -
Clear explanations:
Each question is checked for plain language, answer-choice clarity, and an explanation that helps after a wrong answer. -
Foundational nursing review:
Winona Suzanne Ball, RN, MHS, helped establish the nursing review standards behind Nurse Plus. New updates are maintained by the Nurse.plus content team and checked before publication. -
Editorial QA:
Before a question goes live, we review the clinical point, the distractors, formatting, proofreading, and whether the item fits the test it appears in. -
User feedback:
Every question can be reported from the test screen. When a learner flags wording, an answer choice, or a rationale, we review it and update the item when needed. -
Ongoing updates:
We refresh examples, explanations, and provider references as NCLEX testing guidance changes.
That process is not flashy, but it matters: learners need practice questions that read like the exam and explanations that actually help after a missed answer.
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